1. (3 points) The Netherlands breast-cancer study is described in John Quackenbush's article on Microarray Analysis and Tumor Classification. The Netherlands breast-cancer study differs from the study finding the BRCA1 gene, in both the medical question asked, biological method used, and statistical technique used.

Using 1-2 sentences for each, what were the specific medical questions asked in each of these studies?

2. (3 points) Using 1-2 sentences for each, what were the biological methods used in each of these studies?

3. (4 points) Speculate as to the interpretation, if the gene BRCA1 showed up as a finding in both studies.